Table 3.
Association between change in PhNR amplitude and ocular variables: univariate and multivariable analysis
| Variables | Change in PhNR amplitude, µV | |||||
| Univariate model | Multivariate model 1 | Multivariate model 2 | ||||
| Coefficients | P value | Coefficients | P value | Coefficients | P value | |
| (95% CI) | (95% CI) | (95% CI) | ||||
| Age (years) per 1 year. | 0.00 (−0.12 to 0.13) | 0.986 | 0.02 (−0.09 to 0.14) | 0.712 | 0.01 (−0.11 to 0.13) | 0.825 |
| Gender (male/female) | −0.34 (−3.37 to 2.69) | 0.823 | ||||
| CCT (μm) per 1 µm | 0.04 (−0.01 to 0.09) | 0.157 | ||||
| Axial length (mm) per 1 mm | −0.25 (−1.09 to 0.58) | 0.544 | ||||
| Preoperative BCVA, log MAR, per one unit | −2.67 (−7.62 to 2.28) | 0.284 | ||||
| Preoperative IOP per 1 mm Hg | 0.09 (−0.14 to 0.33) | 0.429 | ||||
| Preoperative MD value, per 1 dB | −0.10 (−0.35 to 0.16) | 0.449 | ||||
| Preoperative RNFL thickness, per 1 µm | −0.08 (−0.19 to 0.03) | 0.163 | ||||
| Type of glaucoma surgery (trabeculectomy/ex-PRESS) |
−0.67 (−3.64 to 2.30) | 0.652 | ||||
| Postoperative BCVA, log MAR, per one unit | −1.32 (-6.13 to 3.49) | 0.584 | ||||
| Change in BCVA, log MAR, per one unit | 2.53 (−4.54 to 9.59) | 0.477 | ||||
| Postoperative IOP, per 1 mm Hg | 0.43 (0.04 to 0.83) | 0.031 | 0.17 (−0.23 to 0.57) | 0.403 | 0.17 (−0.24 to 0.58) | 0.408 |
| Change in IOP, per 1 mm Hg | −0.04 (−0.25 to 0.17) | 0.698 | ||||
| Postoperative CD (yes/no) | −6.88 (−10.13 to –3.63) | ＜0.001 | −6.41 (−10.03 to –2.80) | 0.001 | ||
| Postoperative CD (reference: no) | ||||||
| Grade 1 | −7.64 (−14.67 to –0.60) | 0.034 | −7.26 (−14.43 to –0.08) | 0.048 | ||
| Grade 2 | −5.04 (−9.62 to –0.45) | 0.032 | −4.60 (−9.62 to 0.42) | 0.072 | ||
| Grade 3 | −8.80 (−13.88 to –3.72) | 0.001 | −8.15 (−13.63 to –2.67) | 0.004 | ||
| Past cataract surgery (yes/no) | −0.07 (−3.48 to 3.33) | 0.965 | ||||
| Past glaucoma surgery (yes/no) | 2.23 (−2.96 to 7.41) | 0.393 | ||||
| Past vitrectomy surgery (yes/no) | 6.17 (−1.69 to 14.02) | 0.121 | ||||
| Past cerebrovascular event (yes/no) | 1.35 (−5.26 to 7.95) | 0.685 | ||||
| Self-reported hypertension (yes/no) | −1.67 (−4.77 to 1.43) | 0.286 | ||||
| Self-reported diabetes (yes/no) | 2.17 (−1.41 to 5.74) | 0.229 | ||||
BCVA, best-corrected visual acuity; CCT, central corneal thickness; CD, choroidal detachment; IOP, intraocular pressure; logMAR, logarithm of the minimum angle of resolution; MD, mean deviation; PhNR, photopic negative response; RNFL, retinal nerve fibre layer.