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. 2023 Aug 23;13:13744. doi: 10.1038/s41598-023-40930-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CAR helps to reduce iron overload-induced NLRP3 inflammasome vesicle production in chondrocytes. (a,b) Chondrocytes were treated with 100 μm FAC and co-cultured with 0, 2.5, and 5 μm CAR, and IL-18, IL-1β, and NLRP3 protein levels were observed using protein blots, and the statistical results are shown in the bar graph, which indicates that CAR reduced FAC-induced NLRP3 inflammasome production in a concentration-dependent manner. (c) Immunohistochemistry staining of NLRP3 (Scale bar = 200 μm). (d) Number of NLRP3 positive cells per area. (data are presented as standard deviation ± mean; # P < 0.0001, *** P < 0.001, ** P < 0.01, * P < 0.05 vs Mod).