TABLE 2.
Baseline characteristics of VDAART’s intent-to-treat population for the primary outcome of offspring asthma or recurrent wheezing by the age of 6 y (N paired mother and child = 806)1
| 4400 IU/d of vitamin D n = 405 | 400 IU/d of vitamin D n = 401 | P value | |
|---|---|---|---|
| Maternal age in y (mean ± SD) | 27.5 ± 5.5 | 27.2 ± 5.6 | 0.452 |
| Gestational age at enrollment in wks (mean ± SD) | 14.1 ± 2.8 | 14.2 ± 2.7 | 0.787 |
| Maternal asthma: yes | 171 (42.2) | 151 (37.7) | 0.211 |
| Paternal asthma: yes | 100 (24.7) | 87 (21.7) | 0.370 |
| Maternal 25(OH)D at enrollment in ng/mL (mean ± SD) | 23.3 ± 10.3 | 22.6 ± 10.2 | 0.308 0.583 |
| <12 ng/mL | 55 (13.7) | 52 (13.0) | |
| 12–20 ng/mL | 105 (26.1) | 118 (29.6) | |
| 20–30 ng/mL | 147 (36.6) | 148 (37.1) | |
| ≥30 ng/mL | 95 (23.6) | 81 (20.3) | |
| Mother’s race | 0.886 | ||
| African American | 175 (43.2) | 172 (42.9) | |
| White | 161 (39.8) | 165 (41.1) | |
| Other | 69 (17.0) | 64 (16.0) | |
| Maternal education college or higher | 134 (33.1) | 139 (34.7) | 0.69 |
| Marital status | 0.593 | ||
| Married | 177 (43.9) | 190 (47.4) | |
| Divorced or separated | 12 (3.00) | 10 (2.50) | |
| Not married | 214 (53.1) | 201 (50.1) | |
| Household income | 0.791 | ||
| <$50,000 | 171 (42.2) | 170 (42.4) | |
| ≥$50,000 | 139 (34.3) | 130 (32.4) | |
| Refused to say or unknown | 95 (23.5) | 101 (25.2) | |
| Study site | 0.651 | ||
| Boston, MA | 117 (28.9) | 123 (30.7) | |
| San Diego, CA | 135 (33.3) | 139 (34.7) | |
| St Louis, MO | 153 (37.8) | 139 (34.7) | |
| Male sex of child | 201 (49.6) | 220 (54.9) | 0.157 |
| Preterm birth (<37 wk): yes | 40 (9.9) | 31 (7.7) | 0.331 |
| Season of blood drawn at enrollment | 0.783 | ||
| Winter | 93 (23.0) | 101 (25.2) | |
| Spring | 134 (33.1) | 130 (32.4) | |
| Summer | 99 (24.4) | 88 (21.9) | |
| Fall | 79 (19.5) | 82 (20.4) |
Abbreviation: VDAART, Vitamin D Antenatal Asthma Reduction Trial.
1
Data are given as a number (percentage) of individuals, unless otherwise specified.