TABLE 5.
Hazard ratios for diabetes by BMI and intratrial mean 25(OH)D concentration
| BMI category | Intratrial mean 25(OH)D concentrations |
|||
|---|---|---|---|---|
| <20 ng/mL (<50 nmol/L) | 20 to <30 ng/mL (50–74 nmol/L) | 30 to <40 ng/mL (75–99 nmol/L) | ≥40 ng/mL (≥100 nmol/L) | |
| Group 1 | ||||
| N | 54 | 125 | 192 | 330 |
| Minimally adj model1 | 0.93 (0.46, 1.87) | Reference | 1.00 (0.62, 1.60) | 0.50 (0.31, 0.81)∗ |
| Fully adj model2 | 0.94 (0.45, 1.96) | Reference | 0.89 (0.55, 1.45) | 0.42 (0.26, 0.69)∗ |
| Group 2 | ||||
| N | 80 | 196 | 217 | 325 |
| Minimally adj model1 | 1.25 (0.76, 2.05) | Reference | 0.97 (0.66, 1.42) | 0.43 (0.28, 0.66)∗ |
| Fully adj model2 | 1.54 (0.92, 2.56) | Reference | 0.89 (0.61, 1.30) | 0.39 (0.25, 0.59)∗ |
| Group 3 | ||||
| N | 79 | 101 | 129 | 157 |
| Minimally adj model1 | 1.05 (0.60, 1.82) | Reference | 1.03 (0.64, 1.66) | 0.46 (0.27, 0.79)∗ |
| Fully adj model2 | 1.13 (0.65, 1.98) | Reference | 0.97 (0.60, 1.58) | 0.40 (0.23, 0.69)∗ |
| Group 4 | ||||
| n | 28 | 22 | 32 | 35 |
| Minimally adj model1 | 2.75 (0.68, 11.15) | Reference | 2.33 (0.59, 9.18) | 1.76 (0.46, 6.75) |
| Fully adj model2 | 2.39 (0.59, 9.74) | Reference | 1.85 (0.47, 7.28) | 1.42 (0.37, 5.45) |
Group 1: Black, White <30 kg/m2, Asian <25 kg/m2; Group 2: Black, White 30 to <35 kg/m2, Asian 25 to <30 kg/m2; Group 3: Black, White 35 to <40 kg/m2, Asian 30 to <35 kg/m2; Group 4: Black, White ≥ 40 kg/m2, Asian ≥ 35 kg/m2.
∗
Indicates significantly different as compared to reference range.
1
Minimally adjusted model adjusted for randomization; interaction P = 0.832; continuous model interaction P = 0.80.
2
Fully adjusted models adjusted for randomization, race, gender, age, physical activity, statin use; interaction P = 0.754.