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. 2023 Aug 23;13:13746. doi: 10.1038/s41598-023-40134-4

Table 2.

Standardized-mortality ratios for each cause of death following gallbladder cancer diagnosis.

Cause of death  < 1 year 1–3 years  > 3 years Total
Observed SMR(95%CI) Observed SMR(95%CI) Observed SMR(95%CI) Observed SMR(95%CI)
All cause of death 5828 28.37 2583 11.25 982 2.68 9393 11.71
(27.64–29.10) (10.82–11.70) (2.51–2.85) (11.48–11.95)
Non-cancer of death 355 2.21 277 1.53 387 1.31 1019 1.60
(1.99–2.46) (1.36–1.73) (1.19–1.45) (1.51–1.71)
Cardiovascular diseases 165 2.19 126 1.50 150 1.14 441 1.52
(1.87–2.55) (1.25–1.78) (0.97–1.34) (1.38–1.66)
 Diseases of heart 124 2.21 104 1.66 112 1.15 340 1.58
(1.84–2.64) (1.36–2.02) (0.95–1.39) (1.41–1.75)
 Hypertension without heart disease 8 3.07 6 2.00 9 1.72 23 2.12
(1.33–6.05) (0.73–4.36) (0.79–3.27) (1.35–3.19)
 Aortic aneurysm and dissection 1 1.02 3 2.85 1 0.68 5 1.43
(0.03–5.70) (0.59–8.33) (0.02–3.78) (0.46–3.33)
 Atherosclerosis 2 2.19 2 1.98 4 2.88 8 2.41
(0.27–7.91) (0.24–7.15) (0.78–7.37) (1.04–4.76)
 Cerebrovascular diseases 28 1.99 11 0.70 23 0.93 62 1.14
(1.32–2.88) (0.35–1.26) (0.59–1.40) (0.87–1.46)
 Other diseases of arteries, arterioles, capillaries 2 2.30 0 NA 1 0.67 3 0.90
(0.28–8.32) (0.02–3.73) (0.19–2.63)
Infectious diseases 33 3.24 24 2.11 31 1.74 88 2.24
(2.23–4.55) (1.35–3.14) (1.18–2.47) (1.79–2.76)
 Pneumonia and influenza 8 1.45 9 1.46 15 1.55 32 1.50
(0.63–2.87) (0.67–2.77) (0.87–2.56) (1.03–2.12)
 Syphilis 0 NA 0 NA 0 NA 0 NA
 Tuberculosis 0 NA 0 NA 0 NA 0 NA
 Septicemia 20 6.51 9 2.62 9 1.69 38 3.21
(3.97–10.05) (1.20–4.98) (0.77–3.20) (2.27–4.40)
 Other infectious diseases 5 3.67 6 3.92 7 2.80 18 3.34
(1.19–8.55) (1.44–8.54) (1.13–5.78) (1.98–5.28)
Respiratory diseases 18 1.44 13 0.94 24 1.08 55 1.13
(0.86–2.28) (0.50–1.60) (0.69–1.60) (0.85–1.47)
 Chronic obstructive pulmonary disease and allied Cond 18 1.44 13 0.94 24 1.08 55 1.13
(0.86–2.28) (0.50–1.60) (0.69–1.60) (0.85–1.47)
Gastrointestinal diseases 8 4.51 13 6.88 6 2.25 27 4.26
(1.95–8.89) (3.66–11.77) (0.82–4.89) (2.81–6.20)
 Stomach and duodenal ulcers 0 NA 4 12.52 1 2.13 5 4.62
(3.41–32.05) (0.05–11.89) (1.50–10.78)
 Chronic liver disease and cirrhosis 8 5.41 9 5.73 5 2.27 22 4.19
(2.34–10.66) (2.62–10.89) (0.74–5.30) (2.63–6.34)
Renal diseases 12 2.87 2 0.42 13 1.73 27 1.65
(1.48–5.02) (0.05–1.54) (0.92–2.96) (1.09–2.40)
 Nephritis, nephrotic syndrome and nephrosis 12 2.87 2 0.42 13 1.73 27 1.65
(1.48–5.02) (0.05–1.54) (0.92–2.96) (1.09–2.40)
External injuries 11 1.77 9 1.31 10 0.90 30 1.24
(0.88–3.17) (0.60–2.48) (0.43–1.66) (0.84–1.77)
 Accidents and adverse effects 9 1.80 7 1.25 9 0.97 25 1.26
(0.82–3.41) (0.50–2.57) (0.44–1.84) (0.81–1.85)
 Suicide and self-inflicted injury 2 2.60 2 2.44 0 NA 4 1.49
(0.31–9.39) (0.30–8.83) (0.40–3.80)
 Homicide and legal intervention 0 NA 0 NA 1 4.77 1 1.82
(0.12–26.57) (0.05–10.17)
Other cause of death 108 2.14 90 1.55 153 1.50 351 1.67
(1.76–2.59) (1.25–1.91) (1.27–1.75) (1.50–1.85)
 Alzheimers (ICD-9 and 10 only) 8 0.87 12 1.10 34 1.63 54 1.32
(0.37–1.71) (0.57–1.93) (1.13–2.28) (0.99–1.72)
 Diabetes mellitus 14 2.28 13 1.94 18 1.80 45 1.97
(1.25–3.83) (1.03–3.31) (1.06–2.84) (1.43–2.63)
 Congenital anomalies 0 NA 1 5.88 0 NA 1 1.76
(0.15–32.74) (0.04–9.78)
 Certain conditions originating in perinatal period 0 NA 0 NA 0 NA 0 NA
 Complications of pregnancy, childbirth, puerperium 0 NA 0 NA 0 NA 0 NA
 Symptoms, signs and ill-defifined conditions 10 3.87 6 2.00 4 0.77 20 1.85
(1.86–7.12) (0.73–4.35) (0.21–1.96) (1.13–2.86)
 Other 76 2.35 58 1.56 97 1.47 231 1.71
(1.85–2.95) (1.19–2.02) (1.19–1.80) (1.49–1.94)

NA: Not Applicable.