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. 2023 Mar 28;75(3):2672–2680. doi: 10.1007/s12070-023-03708-2

Table 4.

Red-flag signs for detailed investigations of RAS

Category Red-flag Signs
History

Concomitant genital/skin ulcers

Systemic signs suggestive of autoimmune disorders

Drug / food allergy

Ulcer related

Frequent recurrences (in weeks or every month)

Non-healing or longer time for healing (> 6 weeks)

Necrotic ulcer base

Irregular ulcer margin (non-characteristic ulcer)

Mixed ulcers

Ulcers on keratinized mucosa