Fig. 5.

The domain structures of RNA modifying enzyme families. a METTL family members each contains a MTase domain that catalyzes the methylation. b ALKBH family members and FTO all contain Fe²⁺ binding and α-KG binding sites. c YTH-domain-containing family consists of YTHDC1/2 and YTHDF1/2/3. d IGF2BP family members each contains four KH domains and at least one RRM domain. e ADAR family binds dsRNA through RBD domains, whereas DM domains function as deaminase. f TRMT6 only possesses substrate binding sites, whereas TRMT61A/B contains substrate binding sites as well as SAM binding sites. TRMT10C functions as methyltransferase through its SAM-dependent MTase domain. The domain information of TRMT family proteins comes from the Uniprot database