Table 4.

Combined reflective individual nasal symptom scores and combined reflective individual ocular symptom scores from day 2 to day 14 (AM + PM)

Parameter	Treatment	N	Mean (SD)	Source	p value	Treatment difference [95% (CI)]
Combined reflective individual nasal symptom scores (AM + PM)	Change from baseline of nasal congestion severity score (AM + PM)
	MP-AzeFlu	300	− 1.77 (1.620)
	AZE	298	− 0.97 (1.647)	MP. vs. A	< 0.0001	− 0.56 (− 0.73, − 0.39)
	FLU	299	− 1.74 (1.742)	MP. vs. F	0.0108	− 0.22 (− 0.39, − 0.05)
	Change from baseline of runny nose severity score (AM + PM)
	MP-AzeFlu	300	− 2.04 (1.734)
	AZE	298	− 1.20 (1.665)	MP. vs. A	< 0.0001	− 0.65 (− 0.82, − 0.48)
	FLU	299	− 1.88 (1.819)	MP vs. F	0.005	− 0.24 (− 0.41, − 0.07)
	Change from baseline of sneezing severity score (AM + PM)
	MP-AzeFlu	300	− 2.08 (1.695)
	AZE	298	− 1.37 (1.709)	MP vs. A	< 0.0001	− 0.57 (− 0.74, − 0.40)
	FLU	299	− 1.85 (1.767)	MP vs. F	0.0022	− 0.27 (− 0.44, − 0.10)
	Change from baseline of nasal itching severity score (AM + PM)
	MP-AzeFlu	300	− 1.69 (1.651)
	AZE	298	− 1.07 (1.577)	MP vs. A	< 0.0001	− 0.36(− 0.52, − 0.19)
	FLU	299	− 1.55 (1.652)	MP vs. F	0.0534	− 0.16(− 0.32, 0.00)
Combined reflective individual ocular symptom scores (AM + PM)	Change from baseline of itchy eye severity score (AM + PM)
	MP-AzeFlu	300	− 1.17 (1.576)
	AZE	298	− 0.92 (1.543)	MP. vs. A	0.0298	− 0.17 (− 0.32, − 0.02)
	FLU	299	− 0.94 (1.587)	MP vs. F	0.006	− 0.21 (− 0.37, − 0.06)
	Change from baseline of watery eye severity score (AM + PM)
	MP-AzeFlu	300	− 1.24 (1.512)
	AZE	298	− 0.86 (1.508)	MP. vs. A	0.0006	− 0.25 (− 0.40, − 0.11)
	FLU	299	− 0.95 (1.551)	MP vs. F	0.0021	− 0.23 (− 0.37, − 0.08)
	Change from baseline of eye redness severity score (AM + PM)
	MP-AzeFlu	300	− 1.00 (1.467)
	AZE	298	− 0.78 (1.490)	MP. vs. A	0.0621	− 0.13 (− 0.28, 0.01)
	FLU	299	− 0.86 (1.528)	MP vs. F	0.2792	− 0.08 (− 0.22, 0.06)