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. 2023 Jul 27;30:317–331. doi: 10.1016/j.omtm.2023.07.009

Table 2.

Detection of rAAV6 capsid protein in CB-CD34+ HSPCs at 24 and 48 h post-genome-editing treatment

Sample HR% NHEJ% VP3
Producer cell supernatant N/A N/A detected
Untreated N/A N/A not detecteda
RNP 24 h N/A 90.57 not detecteda
RNP/rAAV6 24 h 72.01 22.75 not detecteda
RNP 48 h N/A 90.57 not detecteda
RNP/rAAV6 48 h 73.49 21.27 not detecteda

RNP, RNP/electroporation; RNP/rAAV6, RNP/electroporation/rAAV6.

a

Levels were lower than the reliable detection threshold, which was equivalent to 2.00E4 vg/cell.