Table 2.

Nematode egg counts (mean^a and range) and reduction percentage of faecal egg counts (FECRT^b) after administration of closantel (CLO) and moxidectin (MXD) by the subcutaneous (SC) or oral route alone or co-administered (+) to parasitized lambs.

	EXPERIMENTAL GROUPS
	CLOSC		MXDSC		CLO + MXDSC		CLOoral		MXDoral		CLO + MXDoral		CONTROL
	Mean range	Efficacy (%) [CI]	Mean range	Efficacy (%) [CI]	Mean range	–	Mean range	Efficacy (%) [CI]	Mean range	Efficacy (%) [CI]	Mean range	Efficacy (%) [CI]	Mean range
Day 0	5510	–	5630	–	5440	-	5230	–	5250	–	5590	–	5350
	2600–10200		2200–11200		2600–8200		1600–8100		1400–8400		2000–12000		2300–9300
Day 2	790 b	85 [69–93]	150 ab	97 [89–99]	10a	99 [98–100]	630 b	88 [77–94]	240 ab	96 [89–98]	20a	99 [98–100]	5420
	0–2400		0–900		0–100		0–1400		0–1000		0–100		900–14800
Day 6	530 b	86 [72–93]	250a	93 [74–98]	50a	99 [96–100]	550 b	85 [69–93]	340 ab	91 [72–97]	40a	99 [95–100]	3680
	0–1000		0–1600		0–200		0–1700		0–1600		0–200		300–8200
Day 10	460 bc	89 [77–94]	140 ab	97 [91–99]	30a	99 [97–100]	770c	81 [66–89]	530 bc	87 [72–94]	20a	99 [98–100]	4030
	0–1100		0–600		0–200		0–1700		0–1300		0–100		1200–7700
Day 13	830 b	85 [72–92]	430 b	92 [85–96]	10a	99 [99–100]	890 b	84 [71–91]	1140 b	80 [62–89]	20a	99 [97–100]	5580
	0–2200		0–1200		0–200		0–1800		100–2600		0–200		2600–11100
Day 22	863 b	82 [67–91]	975 b	80 [61–90]	75a	98 [95–100]	850 b	83 [73–89]	888 b	82 [53–93]	100a	98 [93–99]	4875
	200–1900		100–2100		0–300		400–1300		0–2500		0–400		1000–9200
Day 28	650	84 [57–94]	1013	74 [38–89]	425	89 [66–97]	1350	66 [36–82]	1525	61 [6–84]	688	83 [65–91]	2450
	100–2100		0–3000		0–1400		300–2600		200–4900		200–1500		200–6100

CI: confidence limit 95%. Nematode egg counts at same day post-treatment with different superscript (a, b, c or d) are statistically different at P < 0.05.

^aArithmetic mean.

^bFECRT estimated according to Coles et al. (1992).