Table 3.
OCT analysis of culprit lesion.
| Overall population (n = 249) | Sex |
p value | ||
|---|---|---|---|---|
| Male (n = 206) | Female (n = 43) | |||
| Quantitative assessment | ||||
| Distal reference lumen area, mm2 | 5.4 (4.1, 6.7) | 5.5 (4.3, 6.8) | 4.4 (3.6, 6.0) | 0.003 |
| Proximal reference lumen area, mm2 | 6.8 (5.7, 8.2) | 6.9 (5.8, 8.2) | 6.0 (4.4, 7.6) | 0.010 |
| Minimum lumen area, mm2 | 1.9 (1.4, 2.7) | 1.9 (1.4, 2.8) | 1.8 (1.3, 2.4) | 0.322 |
| Minimum lumen diameter, mm | 1.5 (1.3, 1.8) | 1.6 (1.3, 1.9) | 1.5 (1.3, 1.7) | 0.316 |
| Minimum stent area, mm2 | 6.6 (5.4, 7.8) | 6.6 (5.6, 7.9) | 6.1 (4.7, 7.5) | 0.073 |
| Maximal NIH, % | 0.7 (0.6, 0.8) | 0.7 (0.6, 0.8) | 0.7 (0.5, 0.8) | 0.861 |
| Mean intimal thickness | 0.7 (0.5, 0.8) | 0.7 (0.5, 0.8) | 0.6 (0.4, 0.8) | 0.285 |
| Qualitative assessment, n (%) | ||||
| Neointima characteristics at lesion | ||||
| Neoatherosclerosis | 196 (78.7) | 169 (82.0) | 27 (62.8) | 0.005 |
| Lipid neointima | 187 (75.1) | 160 (77.7) | 27 (62.8) | 0.040 |
| Lipid-rich plaque | 159 (63.9) | 139 (67.5) | 20 (46.5) | 0.009 |
| Maximum lipidic arc, | 300.0 (205.8, 360.0) | 305.5 (209.4, 360.0) | 270.0 (150.0, 360.0) | 0.315 |
| Calcified neointima | 26 (10.4) | 26 (12.6) | 0 (0) | 0.029 |
| Spotty calcification | 15 (6.0) | 15 (7.3) | 0 (0) | 0.141 |
| Re-stenotic tissue structure | 0.047 | |||
| Homogeneous | 57 (22.9) | 41 (19.9) | 16 (37.2) | |
| Heterogeneous | 142 (57.0) | 123 (59.7) | 19 (44.2) | |
| Layered | 50 (20.1) | 42 (20.4) | 8 (18.6) | |
| Distribution of ISR | 0.401 | |||
| Focal | 57 (22.9) | 45 (21.8) | 12 (27.9) | |
| Multifocal | 95 (38.2) | 77 (37.4) | 18 (41.9) | |
| Diffuse | 97 (38.9) | 84 (40.8) | 13 (30.2) | |
| Restenotic tissue backscatter | 0.042 | |||
| High | 88 (35.3) | 67 (32.5) | 21 (48.8) | |
| Low | 161 (64.7) | 139 (67.5) | 22 (51.2) | |
| TCFA | 81 (32.5) | 77 (37.4) | 4 (9.3) | <0.001 |
| Neointimal rupture | 42 (16.9) | 36 (17.5) | 6 (14.0) | 0.575 |
| Thrombus | 32 (12.9) | 24 (11.7) | 8 (18.6) | 0.215 |
| Neointimal macrophages | 94 (37.8) | 87 (42.2) | 7 (16.3) | 0.001 |
| Microvessels | 67 (26.9) | 58 (28.2) | 9 (20.9) | 0.331 |
| Underexpansion | 7 (2.8) | 5 (2.4) | 2 (4.7) | 0.768 |
Values are n (%) or median with first and third quartiles. ISR: in-stent restenosis; MLA: minimum lumen area; NIH: neointimal hyperplasia; TCFA:thin-cap fibrous atherosclerosis.