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Phenotypic experiments on GBM cells. (a) The Western blot results showed a significant increase in the expression levels of HAS2 in U138, U87 and U251 cells; successfully constructed HAS2-OE (b) and HAS2-KO (c) cells. (d) U138-HAS2-OE cells secrete more HA; (e) HAS2-OE promotes the proliferation of GBM cells, while HAS2-KO has the opposite effect; (f) GBM cells with HAS2-OE have a higher migration rate than the control cells. *P < 0.05, **P < 0.01, ***P < 0.001.
