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. 2023 Aug 3;26(9):107536. doi: 10.1016/j.isci.2023.107536

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

The effect of KOR conditional knockdown for the depressive-like behaviors

(A) Above: Timeline of the experiment. Below: Diagram of virus injection and representative coronal images of the injection site. The virus AAV-hSyn-Cre-mCherry was microinjected bilaterally in the NAc of KOR^loxp/loxP mice to knockdown the KOR.

(B) Left: The baseline of the sucrose preference before the injection of morphine. Right: The sucrose preference after the 4 weeks withdrawal.

(C) The immobility latency and immobility time in the TST.

(D) The immobility latency and immobility time in the FST. n = 9 per group. ∗∗p < 0.01, ∗∗∗p < 0.001. The behavioral data were analyzed with two-way ANOVA, followed by Sidak’s post hoc test. Sal-treated WT mice were compared with Mor-treated WT mice. Mor-treated WT mice were compared with Mor-treated cKO mice. The values represent the mean ± SEM.