Acetyl and butyrylcholinesterase Inhibitory activities of compounds 4a–4ya.
| Compounds | AChE | BChE |
|---|---|---|
| IC50 (μM) ± SD | IC50 (μM) ± SD | |
| 4a | NA | NA |
| 4b | NA | 14.7 ± 0.8297 |
| 4c | 148.1 ± 0.7700 | 93.3 ± 0.8208 |
| 4d | 67.0 ± 0.8623 | 44.7 ± 0.8461 |
| 4e | 74.2 ± 0.7970 | 142.5 ± 0.7698 |
| 4f | 131.4 ± 0.8634 | 117.1 ± 0.8046 |
| 4g | 36.3 ± 0.7874 | 239.2 ± 0.8209 |
| 4h | 27.8 ± 0.7232 | 19.0 ± 0.8625 |
| 4i | 45.4 ± 0.6736 | 65.7 ± 0.7662 |
| 4j | 39.1 ± 0.7811 | 84.6 ± 0.7276 |
| 4k | 47.3 ± 0.7912 | 75.1 ± 0.8628 |
| 4l | 33.5 ± 0.9318 | 109.4 ± 0.8708 |
| 4m | 51.1 ± 0.7283 | 60.3 ± 0.6995 |
| 4n | 25.7 ± 0.8137 | 48.6 ± 0.6727 |
| 4o | 40.2 ± 0.8223 | 55.4 ± 0.7870 |
| 4p | 49.1 ± 0.6934 | 110.2 ± 0.8135 |
| 4q | 192.8 ± 0.6493 | 119.6 ± 0.6420 |
| 4r | NA | NA |
| 4s | 91.5 ± 0.6153 | 36.4 ± 0.7022 |
| 4t | 37.7 ± 0.6853 | 78.9 ± 0.6850 |
| 4u | 235.1 ± 0.7335 | 113.5 ± 0.6950 |
| 4v | NA | NA |
| 4w | NA | NA |
| 4x | 186.3 ± 0.8761 | 103.1 ± 0.8765 |
| 4y | 122.6 ± 0.9429 | 101.1 ± 0.9378 |
| SM2 | NA | NA |
| SM3 | 23.1 ± 0.6540 | 21.8 ± 0.8761 |
| Galantamine | 29.5 ± 0.9036 | 27.8 ± 0.8740 |
a
NA = not active, SD = standard deviation.