Figure 2.

Reduction of infarct volume by administration of BMMSCs and iMSCs

(A) 2,3,5-Triphenyl tetrazolium chloride (TTC) staining of rat brains in the vehicle-treated (left), BMMSC-treated (center), and iMSC-treated (right) groups. Sprague-Dawley rats were subjected to transient middle cerebral artery occlusion (tMCAO) and then injected intravenously with BMMSCs, iMSCs, or PBS. The infarct volumes were analyzed by TTC staining 3 days after tMCAO. In TTC staining, normal tissue is stained red, and the infarcted area is unstained. Six sections from one rat brain divided into sections of 2 mm each are shown. One representative rat brain per vehicle, BMMSC, and iMSC group is displayed. (B) Quantitative analysis of the infarct volumes 3 days post tMCAO in each group. The data presented are the means and SDs (∗p < 0.05, n = 5 for each group).