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. 2023 Aug 11;41:20–32. doi: 10.1016/j.jot.2023.06.003

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

MATN3 overexpression inhibits IL-1β-induced ECM degradation and autophagy defects in chondrocytes. A, Analysis of MATN3 expression in IL-1β-induced chondrocytes in microarray GSE104793 (control sample n = 3, IL-1β treated sample n = 3). B, RT-qPCR for MATN3 expression in chondrocytes. C, CCK-8 for the viability of chondrocytes in each group. D-E, ELISA for IL-6 and TNF-α levels in the supernatant of chondrocytes. F, Western blot for expression of MMP-13, ADAMTS5, aggrecan, Collagen II, LC3II/LC3I, and Beclin1 in chondrocytes. ∗ indicates p < 0.05 compared with the control group; # indicates p < 0.05 compared with the IL-1β + oe-NC group. Cell experiments were performed in triplicate.