Table 3.

Parameter Distributions and Values Used As Input to Monte Carlo Analysis for Pediatric Age Groups and Adults

Parametersa	FVL		MPPGL		CYP2E1
Age Group	Distribution and Descriptorsb	Value	Distribution and Descriptors	Value	Distribution and Descriptors	Value
0–30 days, neonate	Normal		Log normal		Gamma
	Mean	0.0412	GM	25.55	Alpha	0.505
	SD	0.0157	GSD	1.001	Theta	26.6
	Lower limit	0.0114	Lower limit	25.53
	Upper limit	0.0775	Upper limit	25.60
31–90 days, infant	Normal		Log Normal		Gamma
	Mean	0.0366	GM	25.68	Alpha	10.7
	SD	0.0102	GSD	1.002	Theta	2.24
	Lower limit	0.0145	Lower limit	25.61
	Upper limit	0.0612	Upper limit	25.74
91 days–2 years, toddler	Normal		Log Normal		Gamma
	Mean	0.0445	GM	26.35	Alpha	4.82
	SD	0.0159	GSD	1.028	Theta	9.42
	Lower limit	0.0274	Lower limit	25.76
	Upper limit	0.1200	Upper limit	27.36
Adult	Normal		Log Normal		Gamma
	Mean	0.0239	GM	35.24	Alpha	11.1
	SD	0.0090	GSD	1.094	Theta	5.33
	Lower limit	0.0136	Lower limit	29.26
	Upper limit	0.0415	Upper limit	40.19

^aFVL (g liver/kg BW, assuming a volumetric density of 1) and CYP2E1 (pmol/mg microsomal protein) were calculated from data in Johnsrud et al. (2003) for specific pediatric age groups. FVL for adults was recalculated from Young et al. (2009). CYP2E1 for adults is from Lipscomb et al. (1997, 2003a, b). MPPGL was estimated on the basis of the equation published in Barter et al. (2008) using subject age in years for all age groups.

^bLower and upper limits are lowest and highest values from data, respectively. Abbreviations: SD, standard deviation; GM, geometric mean; GSD, geometric standard deviation. GM and GSD are log transformed for input into acslx MC routines. For the gamma distribution, alpha is the shape parameter and theta is the scale parameter.