Table 6.
Intragroup and Adult-Child Variability Factors Derived From AUC for BDCM in Venous Blood (AUCv) for Pediatric Age Groups and Adults for Bathing and Oral Scenarios (5 μg/l BDCM in Water)
| AUCv (μg-h/l) |
||||||
|---|---|---|---|---|---|---|
| Age Group | Scenario | 5th% | 50th% | 95th | Intragroup Factora | Adult-Child Factorb |
| Neonate | Bath | 0.0270 | 0.0351 | 0.0940 | 2.68 | 3.55 |
| Infant | 0.0252 | 0.0265 | 0.0294 | 1.11 | 1.11 | |
| Toddler | 0.0238 | 0.0244 | 0.0261 | 1.07 | 0.99 | |
| Adult | 0.0260 | 0.0265 | 0.0276 | 1.04 | ||
| Neonate | Oral | 7.26E-04 | 5.70E-03 | 4.31E-02 | 7.57 | 558 |
| Infant | 8.02E-04 | 1.46E-03 | 2.92E-03 | 2.00 | 37.8 | |
| Toddler | 1.52E-04 | 3.42E-04 | 8.60E-04 | 2.52 | 11.1 | |
| Adult | 3.95E-05 | 7.72E-05 | 1.59E-04 | 2.06 | ||
a
The intragroup variability factor was calculated as the ratio of the 95th percentile value over the 50th percentile value for the same age group.
b
The adult-child variability factor was calculated as the ratio of the 95th percentile value for the child over the 50th percentile value for the adult.