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. 2023 May 3;7(16):4608–4618. doi: 10.1182/bloodadvances.2022009426

Table 2.

MTV and ctDNA values at the times of PET assessment before and after axi-cel

Biomarker Baseline 1 month 3 months
MTV [mL] n = 57 N = 41 N = 56 N = 46
Entire cohort Focused cohort
Median 52.93 42.68 0.74 0
Range 2.3-2256.24 2.3-2106.56 0-3369.13 0-697.97
IQR 283.3 130.24 12.06 15.73 mL
ctDNA [Lg/mL] n = 57 n = 41 n = 54§ n = 42
Entire cohort Focused cohort
Median 95.09 58.1 0 0
Range 0-17903.02 0-6542.75 0-2944.85 0-10291.34
IQR 878.84 856.89 11.98 13.67

Because of unavailable PET, MTV could not be derived for 1 patient not in CR and was marked as 0 mL for 8 patients in CR.

Similarly, MTV could not be derived for 2 patients not in CR and marked as 0 mL for 10 patients in CR.

ctDNA on day 0 was used as baseline in 1 patient without prelymphodepletion ctDNA.

§

ctDNA was not checked in 3 patients without disease progression.

ctDNA was not checked in 11 patients without disease progression.