TABLE 4.

Mixed model comparing inflammatory markers over 24 h between groups, controlling for baseline inflammatory marker level

	Mean difference between esmolol and control at 12 h	P at 12 h	Mean difference between esmolol and group at 24 h	P at 24 h	P for trend over time
Log IL-4 in the first 24 h	−0.02 (−0.89 to 0.84)	0.96	0.39 (−0.45 to 1.24)	0.36	0.85
Log IL-6 in the first 24 h	0.32 (−0.24 to 0.89)	0.26	0.49 (−0.06 to 1.06)	0.08	0.30
Log IL-10 in the first 24 h	0.28 (−0.36 to 0.93)	0.39	0.53 (−0.11 to 1.16])	0.11	0.19
Log TNFα in the first 24 h	0.05 (−0.26 to 0.36)	0.76	0.02 (−0.28 to 0.33)	0.89	0.65
Log CRP in the first 24 h	−0.35 (−0.07 to 0.50)	0.01	−0.50 (−0.77 to [−0.23])	<0.01	<0.01