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. 2023 Jul 28;33:559–571. doi: 10.1016/j.omtn.2023.07.027

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Construction and characterization of EGFR_apt-3WJ-siKRAS^G12C pRNA nanoparticles

(A) Schematic of Alexa 647-labeled EGFR_apt-3WJ-siKRAS^G12C pRNA structure. (B) Native PAGE showing stepwise assembly of EGFR_apt-3WJ-siKRAS^G12C pRNA nanoparticles. (C) DLS assay to assess hydrodynamic size of EGFR_apt-3WJ-siKRAS^G12C pRNA nanoparticles. (D) TGGE assay determined T_m value of EGFR_apt-3WJ-siKRAS^G12C pRNA nanoparticles.