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. 2023 Jul 28;33:559–571. doi: 10.1016/j.omtn.2023.07.027

Figure 4.

Figure 4

EGFRapt-3WJ-siKRASG12C pRNA nanoparticles sensitized NSCLC cells to radiotherapy and chemotherapy

(A) Radiation clonogenic assay was performed and normalized surviving fraction was calculated to evaluate sensitivity of NSCLC cells to radiation treatment after 48 h pRNA treatment. (B and C) Effects of 48 h treatment of EGFRapt-3WJ-siKRASG12C pRNA nanoparticles on cisplatin cytotoxicity on NSCLC cells assessed by both alamarBlue (B) and colony formation assays (C). Error bars represent SD. Significance was calculated using Student’s t test: ∗p < 0.05, ∗∗p < 0.001.