Table 3. Hot Plate-Induced Analgesic Assay^a.

treatment groups	dose (mg/kg)	0 min	30 min	60 min	90 min	120 min
saline	10	9.03 ± 0.64	9.28 ± 0.58	8.27 ± 1.29	9.17 ± 0.71	9.02 ± 0.71
tramal	10	10.32 ± 0.57	26.22 ± 1.07	25.45 ± 2.52***	20.37 ± 0.88***	20.07 ± 1.66***
2a	50	9.02 ± 0.44	14.88 ± 1.43	15.90 ± 0.87**	16.00 ± 0.54***	15.33 ± 1.30**
	75	10.82 ± 0.59	15.68 ± 1.24	16.15 ± 1.71**	16.25 ± 1.40***	15.88 ± 1.07**
	100	9.53 ± 0.38	17.43 ± 0.86	17.55 ± 0.66***	17.60 ± 1.13***	16.82 ± 1.05***
2b	50	9.54 ± 0.32	13.68 ± 1.37	13.95 ± 1.32*	15.10 ± 1.27**	15.72 ± 1.31**
	75	9.58 ± 0.46	14.37 ± 1.29	15.23 ± 0.38**	15.62 ± 1.51***	16.27 ± 1.01***
	100	10.08 ± 0.38	15.98 ± 0.85	16.40 ± 0.66***	16.42 ± 0.68***	16.78 ± 0.54***
2c	50	9.55 ± 0.48	14.30 ± 1.24	15.80 ± 0.66**	13.95 ± 1.11**	13.65 ± 0.97*
	75	10.03 ± 0.75	14.82 ± 0.53	16.78 ± 2.11**	14.30 ± 0.75**	14.02 ± 1.04*
	100	10.80 ± 1.08	16.02 ± 1.02	18.12 ± 1.02***	16.88 ± 1.40***	16.63 ± 1.34***
2e	50	9.06 ± 0.88	13.60 ± 1.23	14.08 ± 1.00*	16.37 ± 1.11***	14.77 ± 1.41**
	75	9.64 ± 0.66	13.95 ± 1.32	14.68 ± 1.11**	16.65 ± 1.44***	15.47 ± 1.39**
	100	10.82 ± 0.58	14.55 ± 0.92	15.65 ± 0.35**	16.68 ± 1.16***	16.38 ± 0.56***
2f	50	10.46 ± 0.28	13.95 ± 1.28	15.68 ± 0.70**	14.83 ± 0.76**	14.70 ± 1.44*
	75	10.42 ± 0.36	17.23 ± 1.71	17.38 ± 1.02***	15.25 ± 1.11**	15.23 ± 1.31**
	100	9.78 ± 0.33	17.43 ± 0.86	17.78 ± 0.96***	15.70 ± 1.54***	15.58 ± 0.93**
2g	50	10.12 ± 0.80	15.18 ± 1.49	15.40 ± 1.09**	15.45 ± 0.83***	14.88 ± 0.52***
	75	10.46 ± 0.68	16.05 ± 1.25	16.45 ± 0.74***	16.57 ± 1.13***	16.50 ± 1.14***
	100	10.10 ± 1.02	16.57 ± 0.56	16.75 ± 0.71***	16.78 ± 1.20***	16.70 ± 1.20***

^aFor group (n = 6), these values are presented as mean ± SEM. The data were analyzed using ANOVA through Dunnett’s test. Compared to negative control, ***p < 0.001, **p < 0.01, and *p < 0.05.