Table 1.

Reported ileostomy neoplasia following total proctocolectomy for ulcerative colitis (UC)

Author, year (reference number)	Age at UC, diagnosis, (years)	Interval from surgery to ICa (years)	Age at ICa (years)	Histology	Lesion pathology
Sigler, 1969 ⁽²⁶⁾	40	19	59	ACa	Adenocarcinoma of an ileal stoma
Cuesta, 1976 ⁽²⁷⁾	29	31	60	ACa	Glandular hyperplasia
Johnson, 1980 ⁽²⁸⁾	39	3	45	ACa	Villous adenoma
Baciewicz, 1983 ⁽²⁹⁾	13	32	45	ACa	Colonic metaplasia and chronic inflammation
Stryker, 1983 ⁽³⁰⁾	41	25	66	ACa	Moderate to severe dysplasia
Suarez, 1985 ⁽¹⁵⁾	25	4	51	ACa	Adenocarcinoma
Bedetti, 1986 ⁽³¹⁾	22	23	45	ACa	Colonic metaplasia and epithelial dysplasia
Vasilevsky, 1986 ⁽³²⁾	22	38	60	ACa	Adenocarcinoma at the ileocutaneous junction
Longo, 1986 ⁽³³⁾	45	28	73	ACa	Adenocarcinoma arising in an ileostomyorifice
Suarez, 1986 ⁽¹⁵⁾	29	4	40	ACa	Ileal carcinoma adjacent to the mucocutaneous junction of an ileostomy
Suarez, 1987 ⁽¹⁵⁾	30	4	70	ACa	Adenocarcinoma adjacent to the mucocutaneous junction of an ileostomy
O’Connell, 1987 ⁽³⁴⁾	34	36	70	SCC	Intestinal and squamous metaplasia
Carter, 1988 ⁽¹⁷⁾	36	43	79	ACa	Severe chronic inflammation, dysplasia and metaplasia
Suarez, 1988 ⁽¹⁵⁾	35	4	60	ACa	Adenocarcinoma adjacent to the mucocutaneous junction of an ileostomy
Smart, 1988 ⁽¹⁸⁾	32	28	60	ACa	Colonic metaplasia and severe dysplasia
Coen, 1988 ⁽³⁵⁾	39	3	42	ACa	Adenocarcinoma of the ileocutaneous junction
Ewing, 1989 ⁽³⁶⁾	28	30	58	ACa	Primary adenocarcinoma
Roberts, 1989 ⁽²²⁾	33	25	58	ACa	Synchronous ileal adenocarcinoma
Roberts, 1989 ⁽²²⁾	23	31	54	ACa	Ileal adenocarcinoma
Berman, 1989 ⁽²⁵⁾	27	34	61	ACa	Colonic metaplasia
Pellissier, 1990 ⁽³⁷⁾	28	33	61	ACa	Severe dysplasia
Ferrandez Rivera, 1990 ⁽³⁸⁾	36	23	59	ACa	Adenocarcinoma at an ileostomy site
Gadacz, 1990 ⁽³⁹⁾	26	34	60	ACa	Colonic metaplasia and focal dysplasia
Carey, 1993 ⁽⁴⁰⁾	28	36	64	ACa	Adenomatous changes, dysplasia and chronic inflammation
Starke, 1993 ⁽¹⁹⁾	27	35	62	ACa	Adenocarcinoma
Listinsky, 1994 ⁽⁴¹⁾	51	11	62	ACa	Neuroendocrine carcinoma
Attanoos, 1995 ⁽¹⁶⁾	33	36	69	ACa	Polypoid mucinous adenocarcinoma
Attanoos, 1995 ⁽¹⁶⁾	37	27	64	ACa	Polypoid invasive adenocarcinoma
Cox, 1997 ⁽⁴²⁾	22	17	39	ACa	Adenocarcinoma involving the intussusception valve
Reissman, 1997 ⁽⁴³⁾	16	48	64	ACa	Colonic metaplasia
Carne, 2001 ⁽⁴⁴⁾	25	41	66	ACa	Squamous cell carcinoma in an ileostomy stoma
Pranesh, 2002 ⁽⁴⁵⁾	20	58	78	ACa	B-cell non-Hodgkins lymphoma of the ileum
Ramanujam, 2002 ⁽⁴⁶⁾	25	51	76	ACa	Squamous cell carcinoma at the stomal site
Abela, 2004 ⁽²⁰⁾	18	30	48	ACa	Colonic-type glands invading submucosa and infiltrate the adjacent skin
Achneck, 2005 ⁽⁴⁷⁾	39	46	85	ACa	Moderately differentiated invasive adenocarcinoma with positive margins
Agibiti, 2005 ⁽⁴⁸⁾		31		ACa	Moderately differentiated adenocarcinoma of the mucocutaneous ileostomy junction
Azem, 2005 ⁽⁴⁹⁾	19	29	69	ACa	Adenocarcinoma
Quah, 2005 ⁽⁵⁰⁾	43	35	78	Peristomal	Adenocarcinoma
Annam, 2008 ⁽²¹⁾	30	35	65	MEC	Mucin-secreting adenocarcinoma
Mohandas, 2010 ⁽⁵¹⁾	13	48	61	ACa	Adenocarcinoma
Chang, 2014 ⁽⁵²⁾	29	21	63	ACa	Well-differentiated squemous cell carcinoma
Procaccino, 2015 ⁽⁵³⁾	35	50	85	ACa	Well-differentiated adenocarcinoma

ICa=ileostomy cancer; ACa=adenocarcinoma; PTC=proctocolectomy; SCC=subcutanous cancer; MEC=malignant epithelial cells