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. Author manuscript; available in PMC: 2023 Aug 24.
Published in final edited form as: Exp Eye Res. 2022 Dec 17;226:109354. doi: 10.1016/j.exer.2022.109354

Fig. 1.

Fig. 1.

Direct ocular exposure to LEW results in an increase of cytokine expression in corneal and retinal mouse tissues 24 h post-exposure. A: Il-6, Ifnγ, Cox2 and Il 1β cytokines expression measured as mRNA fold change was significantly upregulated in the retina, (n = 3–4, *p < 0.05, **p < 0.009). B: The increase in cytokine expression was accompanied by a widespread distribution of TUNEL-positive staining. Average of 3 superior and 3 inferior areas of each control and experimental eyes were used to calculate numbers of TUNEL-positive cells (in green). Nuclei were stained with DAPI. The blue color was substituted by red for better visualization. The RGC, INL cells, and photoreceptor cells (ONL) of the exposed retinas manifested DNA damage, while no staining was observed in the control eyes (n = 3, ****p < 0.0001). Scale bar is 50 μm.