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. Author manuscript; available in PMC: 2023 Aug 24.
Published in final edited form as: Exp Eye Res. 2022 Dec 17;226:109354. doi: 10.1016/j.exer.2022.109354

Fig. 2.

Fig. 2.

Treatment of corneal and retinal endothelial cells results in the upregulation of cytokine expression and UPR activation. A: Treatment of primary human corneal (HCK and HCEC) and retinal (HREC) cells with 200 nM PAO results in the upregulation of cytokine expression (n = 3–6) measured as mRNA fold change. B and C: Simultaneous with the increase in cytokine gene expression, the activation of the PERK UPR signaling pathway was detected 6 h after the treatment. B: Increases in GADD34, and ATF4 were detected in HCK cell line (n = 3). Immunoblot images are shown on the right. C: Increases in GADD34, ATF4, and p-eIF2α were registered for the treated HREC cell line (n = 4). Immunoblot images are shown on the right. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001.