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. Author manuscript; available in PMC: 2023 Aug 24.
Published in final edited form as: Exp Eye Res. 2022 Dec 17;226:109354. doi: 10.1016/j.exer.2022.109354

Fig. 3.

Fig. 3.

Direct ocular exposure of mice to 50 μg PAO arsenical causes severe corneal and retinal injury. A: Both corneal and retinal tissues of the exposed mice manifested cytokine overexpression 24 h later measured as mRNA fold change (n = 3–4). B: The cytokine overexpression was concomitant with the activation of PERK UPR mediators, ATF4, and GADD34 (n = 4). C: Images of western blots treated with antibodies against ATF4, GADD34, and actin. D: The corneal tissue of mice exposed to PAO manifested significant increases in the thickness 72 h later (n = 3). Images of the H&E-stained cornea are shown at the bottom. *p < 0.05, **p < 0.01, ***p < 0.001, and *****p < 0.0001. Scale bar is 50 μm.