FIG. 4.

Effect of treatment with anti-asialo GM1 antibody and l-NMMA on survival of IL-18-treated BALB/c mice infected i.p. with 10⁴ PFU of HSV-1. IL-18 was administered i.p. at 1 μg per mouse daily from day 2 before infection to day 1 after infection. NRS or antibody was injected i.p. on days 3 and 1 before infection and day 1 after infection and every 3 days thereafter. d- or l-NMMA was injected i.p. daily from day 3 before infection to the day of death of all l-NMMA-treated mice injected with the vehicle. Open and closed circles indicate groups of vehicle and IL-18-treated mice (n = 5 per group), respectively. The data is representative of two experiments with similar results. ∗ and ∗∗, P < 0.05 and P < 0.01, respectively.