Table 4. Thermodynamic Parameters Determined from Calorimetric Measurements of Temperature-Dependent Interaction of Fisetin–HRAS1 IM and Morin–HRAS2 IM Complexes.

sample	temp (°C)	N (binding sites)	ΔH (kcal/mol)	TΔS (kcal/mol)	ΔG (kcal/mol)	binding constant (Kb)
Fisetin–HRAS1	30	0.854	–14.79	–8.12	–6.67	9.41 × 104 M–1
Fisetin–HRAS2	30	0.869	–13	–8.69	–4.31	1.34 × 104 M–1
Morin–HRAS2	30	0.239	–338	–336.33	–1.67	2.54 × 104 M–1
Morin–HRAS1	30	0.235	–331	–329.8	–1.20	1.69 × 104 M–1