Table 5. Optimization of the Reaction Molar Ratio for the Synthesis of Compound 4f.
| entry | cyclohexylamine | ethyl cyanoacetate | ethylglycinate hydrochloride | yield (%) |
|---|---|---|---|---|
| 1 | 1 | 1 | 1 | 75 |
| 2 | 1 | 1 | 1.2 | 90 |
| 3 | 1.2 | 1 | 1.2 | 80 |
| 4 | 1 | 1.2 | 1.2 | 80 |
| 5 | 1 | 1 | 1.5 | 85 |
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