Table 2.
Association of HBA copy number with incident ischemic stroke – fully adjusted analyses.
| HR | 95% CI | P value† | |
|---|---|---|---|
| HBA copy number | 1.04 | (0.89,1.21) | 0.66 |
| Age, per year | 1.05 | (1.03, 1.06) | <0.001 |
| Sex | |||
| Female (ref) § | |||
| Male | 0.80 | (0.66, 0.96) | 0.02 |
| Region | |||
| Non-Belt (ref) | |||
| Belt | 1.15 | (0.94, 1.41) | 0.18 |
| Buckle | 1.19 | (0.92, 1.52) | 0.19 |
| Medically insured | |||
| No (ref) | |||
| Yes | 0.87 | (0.62, 1.21) | 0.41 |
| Education level | |||
| < HS Grad (ref) | |||
| HS Grad | 1.13 | (0.87, 1.45) | 0.36 |
| Some College | 0.78 | (0.59, 1.04) | 0.09 |
| ≥ College Grad | 0.75 | (0.55, 1.02) | 0.07 |
| Income | |||
| < $20K (ref) | |||
| $20K - $34K | 1.09 | (0.85, 1.40) | 0.48 |
| $35K - $74K | 1.03 | (0.77, 1.37) | 0.83 |
| ≥ $75K | 0.72 | (0.45, 1.17) | 0.19 |
| Hypertension | 1.51 | (1.09, 2.08) | 0.01 |
| Atrial fibrillation | 1.48 | (1.09, 1.99) | 0.01 |
| Left ventricular hypertrophy | 1.32 | (1.04, 1.67) | 0.02 |
| Smoking status | |||
| Never (ref) | |||
| Past | 1.04 | (0.84, 1.26) | 0.79 |
| Present | 1.62 | (1.25, 2.10) | <0.001 |
| Diabetes mellitus | |||
| No (ref) | |||
| Yes | 1.67 | (1.39, 2.01) | <0.001 |
HBA = alpha globin gene; HR = hazard ratio; CI = confidence interval; ref = reference; HS = high school. Grad = graduate; K = thousand.
†
P values were generated with a Cox proportional hazards multivariable regression employing a linear effect (i.e., additive model for risk) of HBA allele count on the log of the hazard ratio. All variables in the table were included in the multivariable model. Multiple imputations were performed for missing data.