Table 4:

Sensitivity, specificity, and positive predictive value of the four main selection algorithms identified from the literature and our recommended algorithm for identifying Veterans diagnosed with multiple myeloma and for identifying Veterans with multiple myeloma who initiated treatment in VA

Algorithm for multiple myeloma	Sensitivity (95% CI)	Specificity (95% CI)	PPV (95% CI)
Non-VA Algorithm 1	0.86 (0.83–0.88)	0.57 (0.48–0.66)	0.92 (0.90–0.94)
Non-VA Algorithm 2	0.85 (0.82–0.88)	0.57 (0.48–0.66)	0.92 (0.90–0.94)
VA Algorithm 1	0.28 (0.24–0.31)	0.96 (0.91–0.99)	0.98 (0.94–0.99)
VA Algorithm 2	0.63 (0.60–0.67)	0.71 (0.63–0.79)	0.93 (0.90–0.95)
VA Recommended Algorithm	0.45 (0.41–0.49)	0.94 (0.88–0.97)	0.98 (0.95–0.99)
Algorithm for initiation of treatment	Sensitivity (95% CI)	Specificity (95% CI)	PPV (95% CI)
Non-VA Algorithm 1	0.92 (0.89–0.94)	0.28 (0.22–0.35)	0.77 (0.73–0.80)
Non-VA Algorithm 2	0.92 (0.89–0.94)	0.29 (0.23–0.36)	0.77 (0.74–0.81)
VA Algorithm 1	0.35 (0.31–0.40)	0.93 (0.88–0.96)	0.93 (0.88–0.96)
VA Algorithm 2	0.74 (0.70–0.78)	0.64 (0.57–0.71)	0.85 (0.81–0.88)
VA Recommended Algorithm	0.58 (0.54–0.63)	0.89 (0.84–0.93)	0.93 (0.90–0.96)

^*VA Recommended Algorithm includes selection criteria of VA Algorithm 1, but with the removal of height and weight restriction and the addition of requiring at least two billable visits in VA in the three years prior to initial treatment date (to define users of VA).

CI = Confidence Interval; PPV = Positive Predictive Value