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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: J Pediatr. 2023 Apr 4;258:113409. doi: 10.1016/j.jpeds.2023.113409

Table 4.

Population-level results1 for HCV testing strategies among a cohort of children, by proportion of pregnant persons screened for HCV infection, United States, 2022.

Universal testing of all infants
 Testing known exposed
44.7% of pregnant persons
screened (base case)
 65% of pregnant persons
screened
 90% of pregnant persons
screened
Outcome Anti-HCV
with reflex to
HCV RNA at
18 months2,4
(Comparison)		 HCV RNA test at
2-6 months3,5
(Test Strategy 1)		 Anti-HCV with
reflex to HCV
RNA at 18
months2
(Test Strategy 2)		 HCV RNA
test at 2-6
months3
(Test
Strategy 3)		 Anti-HCV with
reflex to HCV
RNA at 18
months2
(Test Strategy 2)		 HCV RNA
test at 2-6
months3
(Test
Strategy 3)		 Anti-HCV with
reflex to HCV
RNA at 18
months2
(Test Strategy 2)		 HCV RNA
test at 2-6
months3
(Test
Strategy 3)
Total costs (2021 USD) 116,433,899 207,170,025 77,621,446 77,151,775 77,383,912 76,635,250 77,590,443 76,244,415
Testing outcomes
 Tested infants 2,709,916 3,076,918 4,478 7,588 6,466 10,993 8,918 15,221
 Anti-HCV tests 2,709,916 0 4,478 0 6,466 0 8,918 0
 HCV RNA tests 6,120 3,076,918 330 7,588 470 10,993 649 15,221
Epidemiologic outcomes among perinatally exposed infants
 Diagnosed HCV infections 553 971 254 443 362 632 498 875
 HCC cases 316 151 419 342 382 275 334 185
 DCC cases 334 157 463 388 416 305 356 197
 Liver transplants 58 28 74 62 68 50 62 34
 HCV Liver-related deaths 550 259 758 626 684 496 588 327
 Treated/cured HCV infections 438 775 196 347 284 501 393 698
 Total QALYs 694,546 696,669 693,059 694,026 693,590 694,967 694,319 696,221
 Total Life-years 1,814,939 1,826,061 1,807,109 1,812,187 1,809,846 1,817,052 1,813,710 1,823,653
1

Assumes 3.6 million births with 0.64% of births occurring among pregnant persons who are HCV RNA+.

2

Assumes 43.0% of children born to HCV RNA+ pregnant persons attend an 18-month visit.

3

Assumes 73.5% of children born to HCV RNA+ pregnant persons attend a 2-6 month visit.

4

Assumes 75.0% of children born to pregnant persons without HCV attend an 18-month visit.

5

Assumes 85.0% of children born to pregnant persons without HCV attend a 2-6 month visit.

Abbreviations: HCV, hepatitis C virus; anti-HCV, hepatitis C virus antibody; USD, United States Dollars; HCC, hepatocellular carcinoma; DCC, decompensated cirrhosis; QALYs, quality-adjusted life-years.