TABLE 3.
Leptin KEGG pathway (STRING tools).
| Term ID | Term description | Genes | p-value |
|---|---|---|---|
| hsa04920 | Adipocytokine signaling pathway | 6 | 3.94E-10 |
| hsa04080 | Neuroactive ligand–receptor interaction | 6 | 1.77E-06 |
| hsa04630 | JAK-STAT signaling pathway | 5 | 1.99E-06 |
| hsa04935 | Growth hormone synthesis, secretion, and action | 4 | 3.85E-05 |
| hsa04917 | Prolactin signaling pathway | 3 | 0.00052 |
| hsa04931 | Insulin resistance | 3 | 0.0015 |
| hsa04152 | AMPK signaling pathway | 3 | 0.0018 |
| hsa04932 | Non-alcoholic fatty liver disease | 3 | 0.003 |
| hsa04024 | cAMP signaling pathway | 3 | 0.0071 |
| hsa01521 | EGFR tyrosine kinase inhibitor resistance | 2 | 0.0298 |
| hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 2 | 0.0342 |
| hsa04659 | Th17 cell differentiation | 2 | 0.0386 |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 2 | 0.0386 |
| hsa05145 | Toxoplasmosis | 2 | 0.0386 |
| hsa04380 | Osteoclast differentiation | 2 | 0.0472 |