Table 3.

The homocysteine levels and headache characteristics changes (after − before) in the study groups

Parameter	Vitamin Group	Placebo Group	p-value
Monthly Headache Frequency	-3 (-4.5 – 0.5)	-1 (-3 – 2)	0.014*
Headache Severity (VAS)	-1 (-2 – 0)	0 (-1 – 1)	0.001*
Headache Duration (Hour)	0 (-1 – 0.5)	0 (-1 – 0)	0.973
Headache Disability (pedMIDAS)	-4 (-8.5 – 2)	-1 (-2 – 2)	0.002*
Homocysteine (μmol/L)	-2.45 (-5.34 – 1.72)	0.1 (-1.86 – 1)	0.040*

PedMIDAS, pediatric migraine disability assessment score; VAS-pain, visual analog scale for pain.

Statistical comparisons were done by Mann–Whitney U-test.

*Statistically significant (p<0.05).