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. 2023 Aug 24;5(3):lqad076. doi: 10.1093/nargab/lqad076

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© The Author(s) 2023. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Recombination between HEG DNA binding domains generates sequence duplication. (A) Schematic of predicted recombination events between related repeats in ICP1 gp174, a T5orf172 HEG encoding a CapR DNA binding domain. Repeat sequences where predicted recombination occurred are bolded and underlined in the nucleotide sequence below. gp174* represents alleles of gp174 with an in-frame deletion of the repeated sequences. (B) Gene graph comparison of the T5orf172 HEGs from phages Helene, 1.187.F1, and MW824372. The green highlighted region represents the T5orf172 domain of each protein and the black boxes labeled 1–6 represent the repeat domains present in the HEGs in phage Helene. Percent nucleotide identity between the sequences is shown by the shaded parallelograms below the gene graph. (C) A pairwise percent nucleotide identity matrix between the 6 repeat regions of Helene T5orf172 HEGs shown in (B).