Table 4.

Metabolic pathways associated with the highest tertile (T3) of baseline CQI.

MetaCyc ID	Pathway	ẞ Coef.	Std. err.	p-value	FDR
PWY-6471	Peptidoglycan biosynthesis IV	0.2325	0.0642	0.0003	0.0064
PWY-6749	CMP-legionaminate biosynthesis I	0.2955	0.0825	0.0004	0.0071
CENTFERM-PWY	Pyruvate fermentation to butanoate	0.4072	0.1200	0.0007	0.0109
PWY-6590	Superpathway of Clostridium acetobutylicum acidogenic fermentation	0.4172	0.1229	0.0007	0.0109
PWY490–3	Nitrate reduction_VI	0.2145	0.0716	0.0029	0.0338
PWY-7456	β-(1,4)-mannan degradation	0.2406	0.0823	0.0036	0.0409
PWY-5177	glutaryl-CoA degradation	0.3461	0.1187	0.0037	0.0415

Associations tested with generalized linear models. Recruiting center (Alicante, Barcelona, Reus, Valencia), smoking status (former smoker, never smoked, smoker), diabetes status, sex, age categories (below the median, < 65 years old; above the median, > 65 years old), and intervention group (CG, IG) set as fixed effect; participant ID set as random effect. Multiple testing correction performed with the Benjamini-Hochberg procedure and features with FDR < 0.1 reported (Reference: Tertile 1).