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(A) Kaplan-Meier plot of time to first moderate or severe chronic obstructive pulmonary disease (COPD) exacerbation over 24 weeks in the ENHANCE-1 trial (modified intention-to-treat population [mITT]). Hazard ratio versus placebo (95% confidence interval [CI]), 0.62 (0.39, 0.97); P = 0.038. (B) Kaplan-Meier plot of time to first moderate or severe COPD exacerbation over 24 weeks in the ENHANCE-2 trial (mITT). Hazard ratio versus placebo (95% CI), 0.58 (0.38, 0.87); P = 0.009.
