Table 5:
Parameters of CogDrisk-AD for predicting Alzheimer disease in the four cohort studies.
| SNAC-K | HRS ADAMS | CHS-CS | MAP | |
|---|---|---|---|---|
| Risk and protective factors | (13) Age, Gender, Education, Diabetes, Stroke, Hypertension, Smoking, TBI, Depression, Loneliness, Physical activity, Cognitive Activity and Fish intake | (9) Age, Gender, Education, Diabetes, Stroke, Smoking, TBI, Depression and Cognitive activity | (10) Age, Gender, Education, Diabetes, Stroke, Smoking, Depression, Loneliness, Physical activity and Fish intake | (13) Age, Gender, Education, Diabetes, Stroke, TBI, Hypertension, Smoking, Depression, Loneliness, Physical activity, Cognitive activity and Fish intake |
| n | N=1579, M=638, F=941 | N=594 M=336, F=258 | N=2701, M=1105, F=1596 | N=850, M=210, F=640 |
| AUC Male | 0·65 (0·50, 0·80) | 0·73 (0·66, 0·80) | 0·72 (0·68, 0·77) | 0·66 (0·59, 0·74) |
| AUC Female | 0·72 (0·62, 0·83) | 0·73 (0·67, 0·78) | 0·72 (0·68, 0·76) | 0·65 (0·61, 0·70) |
| AUC Overall | 0·69 (0·60, 0·78) | 0·72 (0·68, 0·77) | 0·72 (0·69, 0·75) | 0·66 (0·62, 0·70) |
| Reduced variable Model | (12) Age, Gender, Education, Diabetes, Stroke, Hypertension, Smoking, TBI, Depression, Loneliness, Cognitive activity and Fish intake | (8) Age, Gender, Education, Diabetes, Stroke, Smoking, TBI, and Depression | (9) Age, Gender, Education, Stroke, Smoking, Depression, Loneliness, Physical activity and Fish intake | (12) Age, Gender, Education, Diabetes, Stroke, TBI, Hypertension, Smoking, Depression, Loneliness, Physical activity and Cognitive activity |
| n | N=2137, M=816, F=1321 | N=671 M=284, F=387 | N=2757, M=1122, F=1635 | N=1511, M=382, F=1129 |
| AUC Male | 0·66 (0·52, 0·80) | 0·72 (0·75, 0·75) | 0·72 (0·67, 0·76) | 0·69 (0·63, 0·74) |
| AUC Female | 0·71 (0·62, 0·80) | 0·70 (0·65, 0·75) | 0·72 (0·68, 0·75) | 0·62 (0·62, 0·69) |
| AUC Overall | 0·69 (0·61, 0·76) | 0·71 (0·67, 0·75) | 0·72 (0·69, 0·74) | 0·67 (0·64, 0·70) |
| Multiple imputed dataset | (15) Age, Gender, Education, Diabetes, Stroke, Hypertension, Smoking, TBI, Depression, Loneliness, Physical activity, Cognitive activity and Fish intake | (9) Age, Gender, Education, Diabetes, Stroke, Smoking, TBI, Depression and Cognitive activity | (11) Age, Gender, Education, Diabetes, Stroke, Smoking, Depression, Loneliness, Physical activity and Fish intake | (13) Age, Gender, Education, Diabetes, Stroke, TBI, Hypertension, Smoking, Depression, Loneliness, Physical activity, Cognitive activity and Fish intake |
| n | N=3068, M=1133, F=1935 | N=853 M=353, F=498 | N=2771, M=1132, F=1639 | N=2176, M=575, F=1601 |
| AUC Male | 0·70 (0·60, 0·81) | 0·76 (0·71, 0·82) | 0·73 (0·69, 0·78) | 0·67 (0·63, 0·72) |
| AUC Female | 0·70 (0·64, 0·76) | 0·75 (0·71, 0·80) | 0·73 (0·70, 0·77) | 0·64 (0·61, 0·67) |
| AUC Overall | 0·70 (0·65, 0·76) | 0·75 (0·72, 0·79) | 0·73 (0·70, 0·75) | 0·65 (0·63, 0·68) |
Abbreviations:
TBI: Traumatic brain injury