Figure 6. The intermediary of an alkyl chloride enables further diversification of carboxylic acid feedstocks.

All yields are isolated unless otherwise noted. ^aReaction conditions: FeCl₃ (3.0 equiv), Na₃PO₄ (3.0 equiv), carboxylic acid (1.0 equiv), and MeCN (0.10 M), 24 h, rt, 427 nm blue LED. ^bYield was determined by ¹H NMR analysis of the crude reaction mixture using 1-methylnaphthalene as an internal standard. ^cAfter irradiation, amine (10 equiv) and KI (1.5 equiv) were added directly to the reaction mixture and heated to 70°C overnight. ^d7.0 equiv of the amine. ^eSee supplemental information for experimental details.