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. Author manuscript; available in PMC: 2023 Aug 24.
Published in final edited form as: J Allergy Clin Immunol. 2022 Dec 29;151(4):1040–1049.e5. doi: 10.1016/j.jaci.2022.11.027

FIG 2.

FIG 2.

The overall structure of the key domains in C1-INH. Regions involved in the serpin function are labeled (PDB: 5DU3).6,7 The RCL is in pink. The P15–P9 portion of the RCL, the hinge domain, is highly conserved and facilitates the insertion of RCL into the β-sheets A (SA).6 The breach region lies on the top of SA, the initial insertion site of RCL. Composed of strands S3A and S5A, the shutter domain is located in the center of SA, which opens and accepts the RCL insertion. The gate region consists of strands 3 and 4 from β-sheets C (S3C and S4C).6–8 PDB, Protein Data Bank; SA, β-sheets A.