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Bacillus phage lysin is not cytotoxic. Cytotoxicity activities of PlyB at the highest concentration were tested on (A) retinal pigment epithelial cells (ARPE-19) and (B) human retinal Muller cells (MIO-M1). PlyB was not cytotoxic to these cells. Data represent the mean ± SEM of percent of cytotoxicity for N >5 samples, *P = 0.0022, ns >0.05. (C) PlyB and GAT were tested for hemolytic activity on erythrocytes, and both were non-hemolytic (two-way analysis of variance, P > 0.05). .
