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. Author manuscript; available in PMC: 2023 Aug 24.
Published in final edited form as: Nat Cell Biol. 2023 Mar 16;25(4):565–578. doi: 10.1038/s41556-023-01103-1

Extended Data Figure 2. Molecular analysis of β cell clusters.

Extended Data Figure 2.

a, Top 4 enriched biological processes for the indicated β cell clusters (p-value was calculated using two-tailed Benjamini-Hochberg). b, Heatmap showing select genes previously identified to be heterogeneously expressed in β cells in each of the indicated β cell clusters. c, Top 5 differentially expressed genes (DEGs) for the indicated β cell clusters. d, Pathway enrichment analysis of DEGs in Cluster 0, Cluster 2, and Cluster 3 β cells ordered by statistical significance (p-value was calculated using two-tailed Benjamini-Hochberg). e, Top 5 transcription factors predicted in Cluster 0, Cluster 2, and Cluster 3 β cells ordered by statistical significance (p-value was calculated using two-tailed Benjamini-Hochberg). f, Trajectory of the different β cell clusters predicted by Slingshot analysis. Source numerical data are available in source data.