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. 2023 Aug 10;14:1198437. doi: 10.3389/fendo.2023.1198437

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Copyright © 2023 Indirli, Lanzi, Arosio, Mantovani and Ferrante

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Physiology of sexual response and effects of antidepressant and antipsychotic drugs. The upper panel shows the four phases of sexual response and the main systems and neurotransmitters involved. The lower panel summarizes the effects of antidepressant and antipsychotic drugs on the different phases of the sexual response cycle: red boxes stand for inhibitory effects, yellow boxes for neutral effect. ↑, increase; ↓, decrease; 5HT, serotonin; 5HT1, serotonin receptor 1; 5HT₁A, serotonin receptor 1A; 5HT₁B, serotonin receptor 1B; 5HT₁D, serotonin receptor 1D; 5HT₂, serotonin receptor 2; 5HT₃, serotonin receptor 3; 5HT₇, serotonin receptor 7; α2, α2 adrenergic receptor; AAPs, atypical antipsychotics; ANS, autonomic nervous system; DA, dopamine; D2, dopamine receptor 2; FSH, follicle stimulating hormone; GnRH, gonadotropin releasing hormone; LH, luteinizing hormone; MAOi, monoamine oxidase inhibitors; NA, norepinephrine; NO, nitric oxide; PRL, prolactin; SNRIs, serotonin/norepinephrine reuptake inhibitors; SSRI, selective serotonin reuptake inhibitors; TCA, tricyclic antidepressants.