FIG. 5.

FIV-induced cytotoxicity in human PBMC cultures infected with either Petaluma or V₁CSF strains. Results are expressed as the percentage of cell death and are assessed relative to uninfected (CONTROL) cultures. Petaluma-infected cultures exhibited increased cytotoxicity at days 7, 10, and 14 p.i., with the greatest difference occurring at day 10 when cell death was 38.9 ± 2.4% (P < 0.05) in infected PBMC compared to 27.0 ± 2.9% in control cultures. In comparison, significant cell death of 32.9 ± 3.7% (P < 0.05) was observed only at day 7 p.i. in V₁CSF-infected PBMC compared to 19.8 ± 2.3% in control cultures. Significant increases in cell death were determined using a two-tailed Student’s t-test (∗, P < 0.05).