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. 2023 Aug 24;11(16):e15791. doi: 10.14814/phy2.15791

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© 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Effects of injury and sex on muscle fatigability and twitch kinetics. Tibialis anterior muscles of 3‐month‐old male (M) and female (F) mice were injured with BaCl₂ injection and analyzed 14 days after injury. (a) Maximal isometric tetanic force (Po) was measured from injured (Inj) and uninjured contralateral (CTL) muscles before and after fatiguing contractions and expressed as a percentage change (n = 7–9). (b, c) Time to peak twitch (b) and half relaxation time (c) were analyzed from maximal twitch force. Data are presented as mean ± SEM. Statistical significance was determined by two‐way mixed ANOVA followed by Tukey's post hoc test.