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. 2023 Aug 10;14:1213344. doi: 10.3389/fimmu.2023.1213344

Figure 1.

Figure 1

Alteration in the frequency of memory populations with Severe SARS-CoV-2 infection. (A) Flow plots depicting gating strategy to identify switched memory (CD19+ CD27+IgD-) and unswitched memory (CD19+ CD27+IgD+) B cells within the memory compartment (CD27+). Images from a representative mild SARS-CoV-2 subject. (B) Comparison of the average frequency of switched to unswitched memory B cells out of the memory compartment (CD27+) within each cohort. Sample size: Healthy controls (HC; N=10), Immunized controls (Imm; N=15), subjects with Mild (N=11) or Severe SARS-CoV-2 infection (N=14). (C) Frequency of switched memory or unswitched memory as a percent of the memory compartment (CD27+) or (D) as a percent of total B cells (CD+19). (E) Correlation of the frequency of unswitched or switched memory B cells as a percentage of CD19 versus levels of TNFα from plasma. Statistics: One-way ANOVA or Pearson correlation, *p<0.05, **p<0.01.