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. 2023 Aug 10;14:1213344. doi: 10.3389/fimmu.2023.1213344

Figure 2.

Figure 2

Increases in the IgD+only memory population with severe SAR-CoV-2 infection. (A) Representative flow plot from severe SARS-CoV-2 infection depicting the IgD+only memory population (CD19+ CD27+ IgD+ IgM-). (B) Comparison of the average frequency of IgD+IgM+ memory or IgD+only memory out of the unswitched memory compartment (CD27+IgD+) within each cohort. Sample size: Healthy controls (HC; N=10), Immunized controls (IM; N=15), subjects with Mild (N=11) or Severe SARS-CoV-2 infection (N=14). (C) Frequency of IgD+only or IgD+IgM+ memory subsets as a percent of the unswitched memory population (CD27+ IgD+). (D) Correlation of the frequency of IgD+only memory B cells with plasma levels of autoreactive IgG antibodies (anti-VH4-34, anti-Chromatin, anti-Smith, or anti-Cardiolipin) normalized to total IgG. Statistics: One-way ANOVA or Pearson correlation, **p<0.01, ***p<0.001.