Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Aug 10;14:1213344. doi: 10.3389/fimmu.2023.1213344

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Castleman, Santos, Lesteberg, Maloney, Janssen, Mould, Beckham, Pelanda and Torres

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

IL-6 and TNFα production by Unswitched and Switched Memory B cells in response to viral TLR ligand stimulation. (A) Representative flow plots from a mild SARS-CoV-2 subject and quantification of IL-6+ or (B) TNFα+ unswitched or switched memory B cells from healthy controls (white, N=3) or subjects with mild SARS-CoV-2 infection (red, N=3) upon PBMC 4 hour in vitro stimulation with 10ug/mL anti-Ig (H+L) F(ab)’2 + 100ng/mL CD40L and with either 1ug/mL TL3RL (Poly I:C), 1ug/mL TLR7/8L (R848), or 2.5ug/mL TLR9L (CpG). Statistics: one way ANOVA, ns not significant, *p<0.05, **p<0.01, ***p<0.001.