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. 2023 Jul 3;55(8):1168–1183. doi: 10.3724/abbs.2023107

Figure 1 .

Figure 1

The process of m 6A RNA methylation and functions of m 6A effector proteins in RNA metabolism

The m 6A effector proteins include writers, erasers, and readers. The role of writers, including WTAP, RBM15/15B, METTL3, and METTL14, is to catalyze the m 6A methylation modification of RNA. The role of erasers such as FTO and ALKBH5 is to mediate the demethylation modification of RNA. The role of readers, namely, IGF2BP1/2/3, YTHDC1/2/3, YTHDF1/2/3, HNRNPA2B1, and HNRNPC, is to read the m 6A signal on RNA to regulate RNA splicing, processing, decay, stability and translation, and other biological processes.